Fasting-Mimicking Science

Fasting-Mimicking Science



In a market full of juice cleanses, meal replacements and fat-loss wonder pills, it would be easy to overlook yet another fasting diet. Depending on your personal goals and maybe even your interest in the newest science, fasting-mimicking might still be worthy of a second glance.

Fasting-mimicking is based on over 25 years of longevity research and won’t completely eliminate food from your plate.

  • Most fasting-mimicking plans last 5 days.
  • The fast will still allow you to eat 800 to 1100 kcal per day.
  • The fast contains high amounts of unsaturated fats but reduces the intake of carbs and protein to a minimum.
  • For long-lasting results, it is recommended to repeat the fast at least twice a year.

Are you excited about fasting without having to give up on food but are skeptical whether fasting-mimicking works as well as a regular fast? There’s always something to gain with sacrifice, right?

It’s an understandable thought. So let’s look at how fasting-mimicking gets you the same benefits as a regular fast without cutting out food completely.


  • Wei, M., Brandhorst, S., Shelehchi, M., Mirzaei, H., Cheng, C. W., Budniak, J., … & Longo, V. D. (2017). Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science translational medicine9(377), eaai8700.
  • Fontana, L., Partridge, L., & Longo, V. D. (2010). Extending healthy life span—from yeast to humans. science328(5976), 321-326.
  • Longo, V. D., & Mattson, M. P. (2014). Fasting: molecular mechanisms and clinical applications. Cell metabolism19(2), 181-192.
  • de Toledo, F. W., Grundler, F., Bergouignan, A., Drinda, S., & Michalsen, A. (2019). Safety, health improvement and well-being during a 4 to 21-day fasting period in an observational study including 1422 subjects. PloS one14(1), e0209353.
  • Caffa, I., Spagnolo, V., Vernieri, C., Valdemarin, F., Becherini, P., Wei, M., … & Nencioni, A. (2020). Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature583(7817), 620-624.
  • Rangan, P., Choi, I., Wei, M., Navarrete, G., Guen, E., Brandhorst, S., … & Longo, V. D. (2019). Fasting-mimicking diet modulates microbiota and promotes intestinal regeneration to reduce inflammatory bowel disease pathology. Cell reports26(10), 2704-2719.
  • Brandhorst, S., & Longo, V. D. (2019). Protein quantity and source, fasting-mimicking diets, and longevity. Advances in Nutrition10(Supplement_4), S340-S350.
  • Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., … & Longo, V. D. (2015). A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan. Cell metabolism, 22(1), 86-99.
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